【经典高分文献阅读】非心脏手术康复患者的胸痛:回顾性分析

Luffy医学频道 2022-08-03

胸痛心脏手术

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经典高分文献阅读·非心脏手术康复患者的胸痛:回顾性分析

Chest pain in patients recovering from noncardiac surgery: A retrospective analysis

非心脏手术康复患者的胸痛:回顾性分析

通讯作者介绍:

Alparslan Turan: Turan博士目前是凯斯西方大学勒纳医学院的麻醉学教授和克利夫兰诊所临床转归研究部的副主任。他历任多个国际期刊的编委,并在超过30多个国际学术期刊担任过审稿人。Turan教授先后领导了24项科研项目,资助总额超过800万美元,在The Lancet,JAMA, Anesthesiology,British Journal of Anaesthesia 等国际著名医学期刊发表SCI论文250余篇,参与出版专著5本,受邀国际学术讲座60余次。他的主要研究方向是围术期转归、术后疼痛、局部麻醉和麻醉作用机制。

Highlights

▪Chest pain is relatively common postoperatively.

▪  Myocardial infarction (MI) is one cause of chest pain after surgery, but chest pain also results from less severe conditions.

▪ Among 3110 patients with chest pain assumed by of cardiac origin, 540 patients (17%) were diagnosed with an MI.

· Mortality among patients with postoperative MI was 17%.

▪ Troponin screening should be routinely considered in postsurgical patients who report chest pain.

强调点:

√   胸痛在术后比较常见。

√   心肌梗塞 (MI) 是手术后胸痛的原因之一,但胸痛也由不太严重的情况引起。

√   在 3110 名心源性胸痛患者中,540 名患者(17%)被诊断为心肌梗死。

√    术后 MI 患者的死亡率为 17%。

√    对于报告胸痛的术后患者,应常规考虑肌钙蛋白筛查。

ABSTRACT

Study objective

Chest pain is relatively common postoperatively. Myocardial infarction (MI) is one cause of chest pain after surgery, but chest pain also results from less severe conditions. Because of its potential severity, chest pain usually prompts the activation of Rapid Response Systems (RRS). While chest pain is a cardinal symptom of myocardial ischemia in the non-surgical setting, the significance and relevance of chest pain after noncardiac surgery remains unclear.

研究主题:

胸痛在术后比较常见。心肌梗塞 (MI) 是手术后胸痛的原因之一,但胸痛也由不太严重的情况引起。由于其潜在的严重性,胸痛通常会促使启动快速反应系统(RRS)。虽然胸痛是非手术环境中心肌缺血的主要症状,但非心脏手术后胸痛的意义和相关性仍不清楚。

Design

We conducted a retrospective analysis of noncardiac surgical inpatients for whom postoperative chest pain triggered our multidisciplinary RRS.

研究设计:

我们对触发多学科RRS(RRS, Rapid Response Systems)的术后胸痛非心脏外科住院患者进行了回顾性分析。

Setting

Surgical wards at Cleveland Clinic, Cleveland, OH.

地点:

克利夫兰诊所外科病房。

Patients

Postsurgical patients after noncardiac surgery in whom the RSS system was activated for chest pain.

患者

非心脏手术后因胸痛而激活 RSS 系统的术后患者。

Interventions

RRS specified interventions like ECG readings, troponin measurements, transfer to ICU.

干预措施

RRS 指定了干预措施,例如心电图波形、肌钙蛋白测量、转移到 ICU。

Measurements

Our primary outcome was MI. Secondary outcomes included the proportion of patients who had an ECG performed, troponin measurements, echocardiography, cardiac catheterization, and were admitted to the Intensive Care Unit (ICU).

测量

我们的主要结局是心肌梗死。次要结果包括进行心电图检查、肌钙蛋白测量、超声心动图、心导管检查和入住重症监护病房 (ICU)的患者比例。

Main results

5850 surgical patients experienced postoperative chest pain and triggered an RRS activation between 2009 and 2019. A total of 3110 patients had troponin T measured within 6 h after RRS activation, and 538 of them (17%) had elevated troponin, meeting the Fourth Universal Definition criteria for MI. Additionally, 2 patients had ST-segment elevation infarction (STEMI) without troponin measurement. Among the 540 patients with MI, only 19 (3.5%) were diagnosed with a STEMI by ECG, 388 (72%) had echocardiography, 43 patients (8%) had cardiac catheterization, 8 patients (1.5%) required emergent cardiac surgery, and 424 (79%) were admitted to an ICU.

主要结果

5850 名手术患者在 2009 年至 2019 年间经历了术后胸痛并触发了 RRS系统。共有 3110 名患者在 RRS 激活后 6 小时内测量了肌钙蛋白 T,其中 538 名(17%)肌钙蛋白升高,符合第四版通用定义MI的标准。此外,2 名患者出现 ST 段抬高梗死 (STEMI),但未进行肌钙蛋白测量。540 例 MI 患者中,仅 19 例(3.5%)经心电图诊断为STEMI,388 例(72%)进行了超声心动图检查,43 例(8%)进行了心导管检查,8 例(1.5%)需要紧急心脏手术, 424 人(79%)被送入 ICU。

Conclusion

Chest pain is a serious clinical sign, often indicating a postoperative myocardial infarction, and therefore should be taken seriously. Troponin screening should be routinely considered in postsurgical patients who report chest pain.

结论

胸痛是一种严重的临床症状,常提示术后心肌梗死,因此应引起重视。对于报告胸痛的术后患者,应常规考虑肌钙蛋白筛查。

SUMMER

图1患者流程图。ICD:国际疾病分类。

表1:患者基本信息

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